Since 1988, MBF Bioscience has forged a rich history of creating innovative products to empower biological researchers with the quantitative analysis tools they need to obtain accurate, unbiased results.
SPINE2D VERSION REGISTRATION
With intelligent image alignment and registration options automatic, yet customizable, state-of-the-art spine detection and real-time interactive visualization of individual dendritic processes and spines at different time points MicroDynamix software is a novel and powerful tool for research involving dendritic spines.Ībout MBF Bioscience: MBF Bioscience LLC integrates the world’s leading microscope systems with our revolutionary quantitative imaging and visualization software to accelerate research in the fields of: stereology, neuron and microvasculature reconstruction, vascular analysis, worm tracking, brain mapping and big image data management in medical research and education. “MicroDynamix software was developed specifically to enable neuroscientists to quickly and easily contribute to our emerging understanding of the role of dendritic spine morphometrics in normal and abnormal neurophysiology,” says Scientific Director of MBF Bioscience, Dr. With its familiar user-controls and software layout, transitioning to MicroDynamix is easy for researchers who use Neurolucida 360 and want to conduct in-depth dendritic-spine analysis research. MicroDynamix is built on the framework developed for Neurolucida 360 software-the revolutionary, industry-leading tool used by neuroscientists to quickly and accurately reconstruct intricate neuronal structures.
Produce customizable, publication-quality graphs and charts right in the software. Analyze your morphometric data using integrated quantitative analysis tools. Verify and fine-tune alignments with user-friendly tools. 
Register and align images using your choice of three methods. Track and quantify dendritic spine persistence, growth, loss, and transience in 3D images captured from a single specimen at different time points in your experiments. This state-of-the-art dendritic-spine analysis application enables users to visualize and quantify spine morphology over time using powerful algorithms and detection methods.ĭeveloped with input and support from the National Institute of Mental Health (NIMH), the new version of MicroDynamix software makes it easier than ever for neuroscientists to obtain accurate 4D dynamic analyses from in vivo images. To further study the usefulness of the LSIQ and the suggested cutoff score, the dimensionality needs to be investigated.Ĭlinical practice low back pain patient reported outcome measure rehabilitation stratification.Williston, VT (February 11th, 2021)- MicroDynamix™ software version 2021 is now available. The Swedish LSIQ shows acceptable measurement properties regarding test-retest reliability and validity. Participants scoring higher on the LSIQ (≥9) showed significantly higher pain and lower disability levels, were of higher age and less physically active. Internal consistency reached a Cronbach Alpha of 0.64. Test-retest demonstrated high reliability for the total score (ICC 2.1 0.94, 95% CI 0.86-0.96). For construct validity, a moderate correlation was shown with the RM (rho 0.58) and the NPRS (rho 0.47). The LSIQ was successfully translated into Swedish. A suggested cutoff score was used to study discriminative ability. Reliability was tested via test-retest (Intra Class Correlation, ICC 2.1) (n = 50) and by analyzing internal consistency (Cronbach Alpha). Construct validity was investigated via the Roland Morris Disability Questionnaire (RM) and the Numeric Pain Rating Scale (NPRS). The LSIQ was translated using international recommendations. 
We included people with low back pain (LBP) seeking primary care (n = 101). The aim was to translate and cross-culturally adapt the LSIQ into Swedish and to test its measurement properties.
The Lumbar Spine Instability Questionnaire (LSIQ) is a patient-reported outcome measure (PROM) suggested to measure clinical instability of the spine.
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